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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
16.97
Human Site:
S1117
Identified Species:
26.67
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1117
K
E
T
E
K
S
D
S
V
T
D
S
G
P
T
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1143
H
D
D
S
S
S
D
S
G
T
P
S
G
P
D
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1129
H
D
D
S
S
S
D
S
G
T
P
S
G
P
D
Dog
Lupus familis
XP_537646
1532
174610
S1117
N
E
A
E
K
S
D
S
V
R
D
S
G
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1114
T
E
T
S
T
S
D
S
A
A
E
A
G
P
T
Rat
Rattus norvegicus
P41516
1526
173202
P1114
S
E
S
E
S
T
S
P
A
A
E
S
G
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1145
K
E
T
E
K
S
E
S
T
S
A
T
G
P
D
Chicken
Gallus gallus
O42130
1553
174974
S1109
G
D
E
S
G
E
E
S
A
A
A
T
G
P
D
Frog
Xenopus laevis
NP_001082502
1579
178601
E1107
L
I
E
E
E
E
A
E
A
N
A
T
G
P
D
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
K1113
E
D
D
D
E
K
E
K
E
D
T
S
G
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
E1071
Y
R
P
D
P
V
K
E
W
Q
R
R
I
K
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1131
K
K
W
K
E
E
Q
K
L
K
E
L
R
E
S
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
E1071
L
E
G
I
L
E
A
E
S
S
K
L
N
N
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
A1087
E
S
V
E
A
A
I
A
G
A
V
D
D
D
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L1052
R
N
A
I
I
Q
E
L
E
N
L
G
F
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
46.6
46.6
80
N.A.
53.3
40
N.A.
60
20
20
20
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
53.3
53.3
80
N.A.
66.6
60
N.A.
80
40
33.3
53.3
N.A.
6.6
N.A.
46.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
0
7
7
14
7
27
27
20
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
27
20
14
0
0
34
0
0
7
14
7
7
7
40
% D
% Glu:
14
40
14
40
20
27
27
20
14
0
20
0
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
7
0
7
0
7
0
0
0
20
0
0
7
67
0
0
% G
% His:
14
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
14
7
0
7
0
0
0
0
0
7
0
0
% I
% Lys:
20
7
0
7
20
7
7
14
0
7
7
0
0
7
0
% K
% Leu:
14
0
0
0
7
0
0
7
7
0
7
14
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
7
7
0
0
0
0
0
0
0
14
0
0
7
7
0
% N
% Pro:
0
0
7
0
7
0
0
7
0
0
14
0
0
74
0
% P
% Gln:
0
0
0
0
0
7
7
0
0
7
0
0
0
0
7
% Q
% Arg:
7
7
0
0
0
0
0
0
0
7
7
7
7
0
7
% R
% Ser:
7
7
7
27
20
40
7
47
7
14
0
40
0
0
7
% S
% Thr:
7
0
20
0
7
7
0
0
7
20
7
20
0
0
27
% T
% Val:
0
0
7
0
0
7
0
0
14
0
7
0
0
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _